AminoGenesis QuadraFill Targeted Deep Wrinkle Filler
While we love wrinkle-fighting ingredients like glycolic acid, Vitamin C and retinol, persistent deep wrinkles won’t succumb to products with just one or two great ingredients . That’s why we formulated the AminoGenesis QuadraFill Targeted Deep Wrinkle Filler with four recently-patented peptides and two wrinkle-eliminating ingredients to fill deep wrinkles and ensure smooth, plump skin.
The Four Peptides: Syn-Tacks, Syn-Coll, Syn-Hycan, Syn-Ake
We at AminoGenesis love using new, exciting, and scientifically-proven ingredients in our product formulations, so we just couldn’t help but pack these four awesome peptides into the QuadraFill Targeted Deep Wrinkle Filler.
The first peptide, Syn-Tacks, acts to increase skin’s firmness and elasticity by stimulating proteins in the Dermal-Epidermal Junction, thereby reversing some of the effects of aging and photodamage (where the dermis and epidermis meet) (CenterChem). Not only does it stimulate structure-supporting proteins, Syn-Tacks also stimulates collagen activity and integrin, a receptor that acts as a bridge between cells and the extracellular matrix (Lotion Crafter), thereby improving skin’s stability and firmness.
Syn-Coll, on the other hand, is a collagen production-stimulating synthetic peptide that also inhibits matrix metalloproteinase I and III (which hinder collagen production ) (Center Chem, Nanotokin). One study found that Syn-Coll increased collagen production by 119% when compared with the positive standard, transforming growth factor beta (TGF-β). A study of 60 participants similarly found that there was a 350% improvement in the appearance of wrinkles when compared with a placebo treatment (Ingredients to Die For)
The third synthetic peptide in our formulation, Syn-Hycan, increases levels of hyaluronan in the skin. Hyaluronan is a critical constituent of the extracellular matrix, which keeps the skin firm and stable. Among Syn-Hycan’s other benefits is its ability to stimulate decorin and lumican (two glycolized proteins) activity that are partially responsible for collagen fibril formation. In turn skin’s structure is “remodeled” to be much more resilient, firm, and stable (DSM, Center Chem)
The fourth and final synthetic peptide, Syn-Ake, reduces the appearance of wrinkles, laughter lines, and other so-called “expressions lines”. What makes this peptide so spectacular is that it reduces the appearance of wrinkles by easing muscle cell contractions by mimicking the paralytic effects of Walgerin-1, a protein in the venom of the temple snake (DSM, Lotion Crafter). Unlike the snake’s venom and the muscle-paralyzer Botox, Syn-Ake was formulated as a safe and painless muscle-relaxer. In a 28-day trial, participants reported a 52% decrease in wrinkles and a 67% decrease in muscle contraction, indicating that Syn-Ake is a promising new ingredient in anti-aging skin care(Sonya Dakar Skin Clinic).
The Two Wrinkle Fighters: Tensup and Noline
Tens’Up is formulated fro Cichorium intybus L. (chicory) root extract. A fast-acting ingredient that tightens skin and encourages collagen synthesis, many claim that Tens’Up’s effects on the skin can be seen within 5 minutes of application (Prospector, Center Chem)! Additionally, Tens’Up was formulated to have sustained-release so that its could keep skin firm for prolonged periods of time (Pioma Chemicals). When coupled with Noline, which fills in deep creases and diminishes the appearance of wrinkles and fine lines, Tens’Up is a promising ingredient for reducing the appearance of aged and wrinkled skin.
Extracted from the evergreen myristica fragrans, macelignan protects skin by inhibiting collagen breakdown via matrix metalloproteinase and encouraging procollagen synthesis ( a preliminary step to collagen synthesis) (Biological and Pharmaceutical Bulletin, Journal of Dermatological Science). A 2008 study from the journal Biological and Pharmaceutical Bulletin also found that macelignan inhibited melanin production, indicating that it is a promising ingredient for skin-whitening and discouraging discoloration. (Biological and Pharmaceutical Bulletin)
Most anti-aging formulations make use of only one or two wrinkle-fighting ingredients that may not always be able to combat persistent, deeply-creased wrinkles. That’s why we formulated the AminoGenesis QuadraFill Targeted Deep Wrinkle Filler with four recently-patented peptides and two wrinkle-combatting ingredients. The natural extract Tens’Up tightens skin and encourages collagen synthesis, whereas Noline fills in deep creases and reduces the appearance of wrinkles. Syn-Tacks and Syn-Coll both stimulate collagen production, among other benefits, while Syn-Hycan increases levels of hyaluronan in the skin and Syn-Ake simulates the benefits of Botox and temple snake venom to safely yet effectively ease muscle cell contractions. Finally, our formulation includes macelignan, an extract from the evergreen myristica fragrans that inhibits melanin biosynthesis and matrix metalloproteinase activity while also encouraging procollagen production.