Even the most casual reader of the AminoGenesis blog will know that amino acids offer an assortment of benefits for the skin, from fighting signs of aging and discoloration, and even promoting wound healing. Amino acids’ ability to both treat and prevent skin cancer and its symptoms number among its most impressive feats. Below we have highlighted some key amino acids to look for in your beauty protects if you wish to improve your defense against skin cancer this summer.
For the best sun protection, you should wear a broad-spectrum sunscreen. Our Wrinkle Arrest Anti-Aging Day Cream SPF 30 was formulated with amino acids in order to pack an extra punch against sun-related damage. For example, our formulation contains L-leucine, which has been shown to inhibit melanin production in a study from the Biological and Pharmaceutical Bulletin.
Similarly, L-valine and L-serine both inhibited the expression of protease-activated-receptor-2 (PAR2), an enzyme which is commonly expressed due to an inflammatory response. Therefore, L-valine and L-serine are both promising ingredients to ease inflammation due to sun over-exposure (US Patent 20120173446). L-histidine, a proven free radical scavenger, also has strong antioxidant capabilities in human skin, and may help in preventing sun-induced free radical damage in human skin (The Journal of Photochemistry and Photobiology)
If you believe that you may have skin cancer, you should first consult with a dermatologist about the best course of action. Nevertheless, several of the amino acids in the AminoGenesis line of products may provide extra support in eliminating cancerous cells. Not only can L-histidine scavenge active single oxygen and hydroxyl radicals, but a study from the journal Enzyme Research found that L-histidine inhibited autotaxin (ATX) by reducing the movements of ATX-stimulated melanoma cells (No To Shinkei, Enzyme Research ). The enzyme ATX is a lysophospholipase that not only encourages melanoma cell proliferation, but also cell metastasis (expansion). Furthermore, many melanomous cells have a higher expression of ATX than non-melanomous cells (Enzyme Research, Journal of Cheminformatics). Although further research is required, it would appear that topically-applied L-histidine may block melanoma cell metastasis and keep the cancerous concentrated to smaller and more manageable patches of skin by inhibiting ATX expression.
Similarly, the amino acid L-methionine was found to be an excellent free radical scavenger when tested on rats’ brain synaptosomes (Acta Biochimica Polonia). A study from the AAPS Journal echoed this sentiment, noting that L-methionine is excellent at combatting oxidative stress in epithelial cells, though science is still unsure of exactly how L-methionine combats sun-damage (AAPS Journal).
Since amino acids in skin care is a relatively new phenomenon, there are regretfully very few studies that explore the effects of topical amino acids on skin cancer protection. Nevertheless, countless studies have demonstrated amino acids’ ability as potent inhibitors of melanogenesis and free radical scavengers as a dietary supplement, or studied on isolated cells. For the best results we suggest trying our AminoGenesis Wrinkle Arrest Anti-Aging Day Cream SPF 30, which is packed full of 17 amino acids and other beneficial ingredients to both hydrate, repair, and protect the skin against sun damage.