When crafting an anti-aging skin care routine, there are common triggers to avoid, such as over-exposure to harmful UV rays, not following a daily skin care routine, and unnecessarily exposing yourself to environmental toxins like tobacco smoke or air pollution. Although it has received less public attention than other causes of aging, glycation and advanced glycation end products (A.G.E.) play a significant role in damaging and aging the skin. To address this concern, AminoGenesis crafted the A.G.E. Control Dual Treatment Anti-Glycation Serum to not only treat glycation-induced signs of aging, but prevent future damage by disrupting the glycation process. The first product to both treat and prevent glycation, 500 participants enrolled in a 60-day trial to test AminoGenesis A.G.E. Control’s efficacy and reported significant improvements in skin firmness, brightness, and the appearance of under eye circles, among numerous other symptoms.
What is Glycation, and What Does It Do to the Skin?
Glycation is a pretty complex biological process. When sugars enters the blood stream, they attach to the free amino groups of amino acids and form an unstable new molecule called a Schiff Base. After further rearrangement, the Schiff Base may turn into a stable Amadori Product. While Amadori Products and Schiff Bases are reversible products, once they react with protein or peptide amino acid residues, they create protein crosslinks which cannot be reversed. Amadori Products may also undergo oxidation, dehydration, and polymerization that can result in advanced glycation end (A.G.E.) products (DermatoEndocrinology).
While the body creates a majority of its own A.G.E. products from ingested food, many A.G.E. are found in food and the body will absorb 10%-30% of these ingested A.G.E. into the bloodstream (DermatoEndocrinology). Many unprocessed, raw meats and animal-products contain A.G.E. products, but new A.G.E. products are formed once these are cooked. Heat-processed foods (fried, roasted, broiled, etc.) and meats contain the highest level of A.G.E. products, with vegetables, legumes, fruits, and breads had the lowest levels (unless they were prepared with fats). The Journal of the American Dietic Association also found that foods cooked at low to mid range temperatures and with more water/fluids (stewed, boiled, or steamed foods) tended to have fewer A.G.E. products than those cooked at high temperatures and those with little to no water involved. So for example, the same study found that roasted or broiled chicken had more than four the times the number of A.G.E. products than were found in portions of poached or steamed chicken (Journal of the American Dietic Association)
What makes glycation particularly detrimental is that it is easily absorbed into body tissue (collagen, vascular muscles, and membranes) and its accumulation depends on the rate of protein turnover. The skin contains several long-lasting proteins and collagens, such as Collagen Type I and IV that wait several years before experiencing turnover, thus giving A.G.E. products ample time to accumulate and damage skin’s appearance (DermatoEndocrinology). By one’s late twenties, glycation is a rampant problem that leads to 3.7% annual accumulation of glycated collagen (Clinics in Dermatology). A.G.E. products tend to gather in environmentally-damaged skin, especially skin damaged by tobacco smoke or UV exposure, with some research indicating the UV radiation may quicken the rate of A.G.E. formation. For example, one study found that patches of non sun-protected skin in young individuals had an increased level of A.G.E. products, as compared to the subjects’ sun-protected patches of skin. (DermatoEndocrinology).
Once A.G.E. products have accumulated in the skin, then cause a wide variety of problems. Once they interact with A.G.E. products, collagen in the skin typically becomes much less flexible and more prone to damage. A.G.E. products also play a role inducing fibroblast apoptosis and a slower rate of fibroblast proliferation, and were found to decrease the viability of UVA-radiated fibroblasts and keratinocytes, in addition to encouraging reactive oxygen species (ROS) formation in UVA-irradiated cells (DermatoEndocrinology). In essence, A.G.E. products accelerate the rate of anti-aging by attaching to or corrupting the capabilities of existing cellular structures and compounds.
How Can AminoGensis A.G.E. Control Dual Treatment Anti-Glycation Serum Help?
Fortunately, the AminoGenesis A.G.E. Control Dual Treatment Anti-Glycation Serum was shown in a 60-day trial study to treat many signs of glycation-induced aging.
The formulation includes albizia julibrissin, a plant extract that has demonstrated potential in combatting glycation. It is believed that this extract is able to interrupt the glycation product and either stop the process, or limit its negative effects. Albizia julibrssin may also help to treat and prevent glycation by detoxifying/neutralizing A.G.E. products (US Patent W02013046137A2).
Though more research needs to be conducted, past studies have indicated that albizia julibrissin may exhibit antioxidant activity (International Journal of Pharmacy and Pharmaceutical Scieces). The julibroside extract in albizia julibrissin has also demonstrated potential as an anti-tumor agent(Bioorganic and Medicinal Chemistry Letters, Bioorganic and Medicinal Chemistry Letters)
Aside from the lightweight, conditioning silicones cyclpentasiloxane and cyclohexasiloxane, AminoGenesis A.G.E. Control also contains the humectant glycerin. In a study from the International Journal of Cosmetic Science, a cream containing 20% glycerin was shown to greatly improve skin barrier strength by encouraging cell turnover and cell maturation. Glycerin also acts as a humectant that helps the skin to retain water. Glycerin works by penetrating the stratum corneum and creating a sort of reservoir (British Journal of Dermatology)
Glycation is unfortunately a problem that almost everyone will face by their late 20’s, perhaps earlier if you eat many heat-processed or sugary, processed food. Advanced glycation end (A.G.E.) products are the result of glycation, and play a significant role in signs of aging, such as wrinkled or dull skin. A.G.E.’s effects can be exacerbated by exposure to tobacco smoke UV rays, and other environmental pollutants, so it is best to avoid undue pollutants as much as possible.
Aside from limiting one’s intake of heat-processed and sugary food, the best way to fight glycation is to use the AminoGenesis A.G.E. Control Dual Treatment Anti-Glycation Serum. Our formulation was designed with glycerin, cyclopentasiloxane and cyclohexasiloxane to hydrate the skin. A.G.E. Control’s shining ingredient is albizia julibrissin, which has demonstrated great potential in both repairing the signs of glycated skin and halting the glycation process.