Histidine is a very important amino acid. As you age, your skin’s natural stores of amino acids, including histidine, becomes depleted. This is both because the stores become depleted due to internal and external stressors, and because your body produces and maintains less amino acids as you age.
Histidine is an antioxidant
Histidine may improve skin’s immunity
Immunity boost for your skin is another benefit. L-histidine and L-isoleucine may help to prevent skin infections when used regularly. Both have been shown to boost immunological activity against certain types of skin infections, whether by increasing activity (L-histidine) or increasing skin’s natural production of anti-microbial peptides (PLoS Pathogens, 2008, Pharmaceuticals, 2014).
Histidine may help wounds heal
Chronic wounds such as venous stasis ulcers have become a socioeconomic problem. Even with successful initial management, the recurrence rate approaches 70%. With the advent of new wound healing agents, nonoperative attempts to heal these wounds appear indicated. This study reports a prospective randomized evaluator-blinded trial comparing two potential wound healing agents to an inert vehicle placebo. Eighty-six evaluable patients completed the trial. Silver sulfadiazine 1% in a cream proved to statistically reduce the ulcer size compared with a biologically active tripeptide copper complex 0.4% cream formulation or the placebo. There was no difference between the latter two treatments. Silver sulfadiazine has been shown to allow keratinocyte replication and to have antiinflammatory properties. In this trial its antibacterial action was not used since all ulcers had comparable bacterial levels (≤ 105/gm of tissue) before treatment. These results suggest that the silver sulfadiazine cream used in this study may facilitate healing in wounds healing largely by the process of epithelization. (J Vasc Surg 1992;16:251–7.)