The best peptides in skin care typically feature the ability to firm sagging skin, improve the appearance of fine lines and wrinkles, and even treat hyperpigmentation. Below, we have insights into some of the best peptides in skin care, and where to find them:
Palmitoyl pentapeptide-3 is amongst the best peptides on the market today. With more substantial research backing than many other peptides, it has been found to have significant effects against signs of aging.
Studies have also shown that palmitoyl pentapeptide increases skin firmness over time (Cosmeceutical Peptides, 2007). An additional study in the International Journal of Cosmetic Science demonstrated that palmitoyl pentapeptide-3 significantly improves the appearance of fine lines and wrinkles. Skin’s overall moisturization levels also improved.
And for the future, there could be significant effects as well. Palmitoyl pentapeptide has been found to result in an increased production of skin-firming collagen and elastin, as well as another protein that is important for your skin’s framework known as fibronectin.
All in all, palmitoyl pentapeptide is a superb anti-aging ingredient. If you must try a single peptide, make it this one!
Where to find it: Based on these studies, a strategy of using palmitoyl pentapeptide-3 could be very beneficial to aging skin. We recommend AminoGenesis Photolagen AGF. It is a superior daily skin care treatment that may help to improve the appearance of fine lines, wrinkles, sun spots, sagging skin, and other signs of UV damage and aging.
SynPeptides: Syn-Tacks, Syn-Coll, Syn-Hycan, and Syn-Ake
Syn-Tacks acts to increase skin’s firmness and elasticity by stimulating proteins in the Dermal-Epidermal Junction, thereby reversing some of the effects of aging and photodamage (where the dermis and epidermis meet) (CenterChem). Not only does it stimulate structure-supporting proteins, Syn-Tacks also stimulates collagen activity and integrin, a receptor that acts as a bridge between cells and the extracellular matrix (Lotion Crafter), thereby improving skin’s stability and firmness.
Syn-Coll is a collagen production-stimulating synthetic peptide that also inhibits matrix metalloproteinase I and III (which hinder collagen production ) (Center Chem,Nanotokin). One study found that Syn-Coll increased collagen production by 119% when compared with the positive standard, transforming growth factor beta (TGF-β).
A study of 60 participants similarly found that there was a 350% improvement in the appearance of wrinkles when compared with a placebo treatment (Ingredients to Die For)
Syn-Hycan, increases levels of hyaluronan in the skin, which keeps the skin firm and stable. Among Syn-Hycan’s other benefits is its ability to stimulate decorin and lumican (two glycolized proteins) activity that are partially responsible for collagen fibril formation. In turn skin’s structure is “remodeled” to be much more resilient, firm, and stable (DSM, Center Chem)
The fourth and final “syn” peptide, Syn-Ake, reduces the appearance of wrinkles, laughter lines, and other so-called “expressions lines”. What makes this peptide so spectacular is that it reduces the appearance of wrinkles by easing muscle cell contractions by mimicking the paralytic effects of Walgerin-1, a protein in the venom of the temple snake (DSM, Lotion Crafter). Unlike the snake’s venom and the muscle-paralyzer Botox, Syn-Ake was formulated as a safe and painless muscle-relaxer. In a 28-day trial, participants reported a 52% decrease in wrinkles and a 67% decrease in muscle contraction, indicating that Syn-Ake is a promising new ingredient in anti-aging skin care(Sonya Dakar Skin Clinic).
Where to find it: Based on these studies, a strategy of using Syn-Tacks, Syn-Coll, Syn-Hycan, and Syn-Ake could be very beneficial to aging skin. We recommend AminoGenesis QuadraFill Targeted Deep Wrinkle Filler . It is a superior daily skin care treatment that may help to improve the appearance of persistent, deeply-creased wrinkles, and other signs of aging.
Like palmitoyl pentapeptide-3, palmitoyl oligopeptide is known for increasing skin firmness. What is great about palmitoyl oligopeptide is that it significantly stimulates collagen production in human fibroblasts, as shown in a 2007 study. When used twice daily for about six months, this resulted in firmer, tighter skin.
On the lips, palmitoyl oligopeptide is also useful because it has been found to regulate elastin expression. Elastin expression naturally increases with age, leading to criss-crossed, disorganized fibrils that can make skin less elastic and more brittle over time. By using products with palmitoyl oligopeptide on the lips, it may be able to help the lips stay more supple over time.
Where to find it: Based on these studies, a strategy of using palmitoyl oligopeptide on the lips could be highly beneficial for aging in this area! We recommend AminoGenesis Lips to Love Instant Lip Plumper. It is a sensational daily lip treatment that may help to plump, firm, and improve the overall smoothness and aged appearance of the lips.
Peptides can be difficult to navigate, but this handy guide to the best peptides in skin care should help to set you straight!
- Palmitoyl pentapeptide-3: Excellent for improving the appearance of fine lines, wrinkles, sagging skin
- Syn Peptides: Excellent for improving the appearance of fine lines, wrinkles, expression lines
- Palmitoyl oligopeptide: Excellent for improving the appearance of aged, lined, thin lips